Katja petri biography of abraham
•
Intellectual disability and computers in therapy: Views of service users and clinical psychologists
Introduction
The bevis for the efficacy and acceptability of internet-delivered psychological interventions for children and adults with mental health problems is growing steadily (Andersson, 2009; Newby, Twomey, Li, & Andrews, 2016; Pennant et al., 2015; Richards, Richardson, Timulak, & McElvaney, 2015); yet people with intellectual disability (ID) have been consistently excluded from this area of research. People with ID present with a below average level of intellectual functioning, as indicated by an IQ below 70, and impairments in their adaptive functioning, which have an age of onset before 18 years of age (World Health Organisation, 1992). The begrepp ”intellectual disability” as a social-ecological construct in relation to someone’s functioning moves away from disability as a person-centred deficit trait and highlights the role of social and environmental factors inom
•
Legatio: The Journal for Renaissance and Early Modern Diplomatic Studies
Archival Sources
Nationaal Archief, Den Haag, Staten-Generaal,
nummer toegang 1.01.02, inventarisnummer 12563.2
Stadssarchief Amsterdam, Notarieel Archief,
SAA NA, 218, fol. 97, 30 May 1622.
SAA NA, 270, fol. 199, 17 Aug. 1613.
SAA NA, 132, fol. 186, 19 Sep. 1613.
SAA NA, 200, fol. 185v, 16 Apr. 1619
SAA NA, 200, fols 185v–188, 16 Apr. 1619
SAA NA, 658, fol. 662, 28 June 1622
Riksarkivet, Stockholm, Kammarkollegiet Ämnessamlingar, Kammarkollegiet skuldböcker, vol. 5
Riksarkivet, Stockholm, Skrivelser till konungen, Skrivelser till Karl IX, vol. 5;
Riksarkivet, Stockholm, Riksregistratur
Riksarkivet, Stockholm, Diplomatica Hollandica, Svenska beskickningars till Holland brev och samling, Svenska sändebud
Printed Primary Sources
Bergh, Severin, Svenska Riksrådets rapport, 1650 (Stockholm: Norstedt 1916)
Kullberg, Nils Axel, Svenska Riksrådets rapport, 1630–1632 (Stockholm: Kongl
•
Abstract
Endogenous circadian clocks have evolved to anticipate 24 hr rhythms in environmental demands. Recent studies suggest that circadian rhythm disruption is a major risk factor for the development of metabolic disorders in humans. Conversely, alterations in energy state can disrupt circadian rhythms of behavior and physiology, creating a vicious circle of metabolic dysfunction. How peripheral energy state affects diurnal food intake, however, is still poorly understood. We here show that the adipokine adiponectin (ADIPOQ) regulates diurnal feeding rhythms through clocks in energy regulatory centers of the mediobasal hypothalamus (MBH). Adipoq-deficient mice show increased rest phase food intake associated with disrupted transcript rhythms of clock and appetite-regulating genes in the MBH. ADIPOQ regulates MBH clocks via AdipoR1-mediated upregulation of the core clock gene Bmal1. BMAL1, in turn, controls expression of orexigenic neuropeptide expression in the MBH. Togeth